3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W Are you sure you want to delete your template? 1 0 obj If breathing is difficult or if . In 1964 FMC, Corporation . PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. . The short-term limit for total inhalable dust is 20 mg/m3. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. It . }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge 4 0 obj Wu, K. Zuurman, H.W. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. The data shown below apply only to Avicel PH 101. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. /Parent 3 0 R Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. <> CAS 9004-34-6, pH 5 - 7.5. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Biologicals by FMC. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Magazine: Material safety data sheet - FMC Corporation. Learn about FMC's industry leading goal of net-zero emissions by 2035. The figure below illustrates the structural organisation of cellulose within plants. Meet our leadership team. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. SDS - Safety Data Sheet. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Truly distinctive drug delivery solutions. /Contents 4 0 R F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. No. 2 0 obj Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. The cellulose molecule is formed through repeated condensation of cellobiose units. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. 4 0 obj The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. MATERIAL SAFETY DATA SHEET. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. }o]X4]. } !1AQa"q2#BR$3br SUBSTANCE IDENTIFICATION 1.1. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Production of Pharmaceutical Grade Microcrystalline Cellulose. The most. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Delivering efficient and robust formulations. Microcrystalline cellulose is a commonly used excipient in the . No. >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream : 160182 Date Approved: 05/25/2010 Revision No. MATERIAL SAFETY DATA SHEET Version: 1.0 1. endobj !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b ( Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. 8 0 obj Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Microcrystalline Cellulose / Avicel PH-102. POLYOX resins are nonionic polyethylene oxide solubility polymers. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. FMC, JRS and Mingtai were estimated to hold for . if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. 4. Catalog Number 102331. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? PDF (4.11 mb) Footer menu 1. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Aqueous suspensions of microcrystalline cellulose have . % 0.25 - 0.37. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. The aqueous solution to barrier membrane coating. Avicel RC-591 & CL-611 - Description. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. undefined. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Revision No. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. MSDS Ref. 2021 Annual Report. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? >> A family of polysaccharide products that allow distinctive drug delivery solutions. : 51395-75-6 Date Approved: 01/31/2008 Revision No. The typical mean particle size is 20200 m. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Product Name: Microcrystalline Cellulose E460 1.2. Eur., JPE . It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. Created Date: 2/10/2020 8:51:41 PM . pH 6.0 to 8.0 . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. << ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM No. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. ( Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Alginates also function as actives in some anti-reflux products. : CL-611NF Date Approved: 01/13/2010. "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC However, consumption of large quantities of the material may have a laxative effect. FMC Corporation. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Microcrystalline Cellulose NF. 6 Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Avicel PC 611 (FMC Biopolymer) Supplied by. Avicel PC 611 (FMC Biopolymer) . on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. 51395-75-6 Avicel RC 591. Heavy metals, % NMT 0.001 Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. endobj Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. BIOACCUMULATIVE POTENTIAL Avicel Microcrystalline Cellulose: Chemical Identifiers. <> Buy Chemicals. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) 1. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. 9,LL!z Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Doses up to 30 g per day appear to be . %PDF-1.4 All rights reserved. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Date Approved: 05/25/2010. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. This Microcrystalline Cellulose . The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. CAS #: 9004-34-6 . Avicel Microcrystalline Cellulose Physical Properties. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . <> Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . };khd5x=fr SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . q9;v80q>jZ Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Synergies to simplify formulation challenges and reduce operational costs.