The Small Molecule Synthesis facility at Duke University was established as a component of the Duke University Center for Chemical Biology in 2003 to provide synthetic organic chemistry capabilities to the entire University community. The Center is located in the Levine Science Research Center, and occupies modern fully hooded synthetic space. The facility has access to all routine synthetic equipment, as well as modern multidimensional NMR (to 800 MHz), various mass spectrometry capabilities (EI & CI double focusing high resolution, GC/MS, LC/MS, electrospray, MALDI) all routine optical spectroscopy, and small molecule diffractometers.